Title

A meta-analysis of prevalence estimates and moderators of low bone mass in people with schizophrenia

Publication Date

2014

Journal Title

Acta Psychiatr Scand

Abstract

ObjectiveTo assess the prevalence and moderators of low bone mass, osteopenia and osteoporosis in schizophrenia patients. MethodMajor electronic databases were searched from inception till December 2013 for studies reporting the prevalence of low bone mass (osteopenia+osteoporosis=primary outcome), osteopenia or osteoporosis in schizophrenia patients. Two independent authors completed methodological appraisal and extracted data. A random effects meta-analysis was utilized. ResultsNineteen studies were included (n=3038 with schizophrenia; 59.2% male; age 24.5-58.9years). The overall prevalence of low bone mass was 51.7% (95% CI=43.1-60.3%); 40.0% (CI=34.7-45.4%) had osteopenia and 13.2% (CI=7.8-21.6%) had osteoporosis. Compared with controls, schizophrenia patients had significantly increased risk of low bone mass (OR=1.9, CI=1.30-2.77, P

Volume Number

130

Issue Number

6

Pages

470-486

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Psychiatry

Additional Departments

Molecular Medicine

PMID

25041606

DOI

10.1111/acps.12313