Title

Quality of life and outcomes in patients60 years of age after allogeneic hematopoietic cell transplantation

Publication Date

2014

Journal Title

Bone Marrow Transplant

Abstract

Hematopoietic cell transplantation (HCT) has become an established standard of care for many older patients with hematologic malignancies. The effect of transplantation on the quality of life (QOL) of older patients, however, has not been well studied. We thus analyzed QOL in patients 60 undergoing an allogeneic HCT compared with patients(FACT-BMT), Coping Inventory and the Profile of Mood State-Short Form. Patients 60 reported better social (P=0.006) and functional well-being (P=0.05) with FACT assessment, and had better total scores, (P=0.043) across all time points. When adjusted for baseline QOL scores as a covariate, social well-being remained significantly better, whereas the other scores became non-significant. With a median follow-up of 49 months, there were no significant differences in OS, relapse-free survival, relapse or chronic GVHD. This study provides further evidence that advanced age should not be a barrier in the decision to pursue allogeneic HCT. Older patients achieved comparable QOL when compared with younger patients.

Volume Number

49

Issue Number

11

Pages

1426-31

Document Type

Article

EPub Date

2014/07/30

Status

Faculty

Facility

School of Medicine

Primary Department

Obstetrics and Gynecology

PMID

25068430

DOI

10.1038/bmt.2014.166