Title

Sepsis: a roadmap for future research

Publication Date

2015

Journal Title

Lancet Infect Dis

Abstract

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research.

Volume Number

15

Issue Number

5

Pages

581-614

Document Type

Article

EPub Date

2015/05/02

Status

Faculty

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Neurosurgery

PMID

25932591

DOI

10.1016/s1473-3099(15)70112-x