Title

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury

Publication Date

2014

Journal Title

N Engl J Med

Abstract

BACKGROUND Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase 3 randomized clinical trial. METHODS We conducted a multinational placebo-controlled trial, in which 1195 patients, 16 to 70 years of age, with severe TBI (Glasgow Coma Scale score,

Volume Number

371

Issue Number

26

Pages

2467-2476

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Neurosurgery

PMID

25493978

DOI

10.1056/NEJMoa1411090