Title
The visceral fat compartment is independently associated with changes in urine constituent excretion in a stone forming population
Publication Date
2015
Journal Title
Urolithiasis
Abstract
The objective of this study was to identify the independent effect of visceral fat on urine constituent excretion in a stone forming population. Using a database of 382 kidney stone patients with available visceral fat quantification, we created multiple linear regression models predicting changes in urinary solutes based on visceral fat area and body mass-index, divided by gender. Chi-square tests were used to compare stone composition by body mass-index and visceral fat area. Visceral fat predicts increases in urinary creatinine, sodium, and volume in men, but only urinary phosphate in women. In women, total body mass-index does not appear to modify this effect, but in men it is more pronounced in overweight patients for creatinine and volume only. Elevated visceral fat is associated with increased probability of uric acid stone composition. Different fat compartments likely effect urine composition in different ways. This effect appears to be different in men and women. Understanding and quantifying the effects of different fat compartments is probably important to understanding the metabolism of urolithiasis.
Volume Number
43
Issue Number
3
Pages
213-220
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Urology
PMID
DOI
10.1007/s00240-015-0770-8