Comparison of optical coherence tomography assessments in the comparison of age-related macular degeneration treatments trials

F. A. Folgar
G. J. Jaffe
G. S. Ying
M. G. Maguire
C. A. Toth

Abstract

OBJECTIVE: To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). DESIGN: Cross-sectional study within the Comparison of AMD Treatments Trials (CATT). PARTICIPANTS: During year 2 of CATT, 1213 pairs of SD OCT and TD OCT scans were compared from a subset of 384 eyes. METHODS: Masked readers independently graded OCT scans for presence of intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid and performed manual measurements of retinal, SRF, and subretinal tissue complex thicknesses at the foveal center. MAIN OUTCOME MEASURES: Presence of fluid was evaluated with percent agreement, kappa coefficients with 95% confidence intervals (CIs), and McNemar tests. Thickness measurements were evaluated with mean difference (Delta) +/-95% limits of agreement and intraclass correlation coefficients (ICCs) with 95% CIs. RESULTS: Between SD OCT and TD OCT, agreement on presence of any fluid was 82% (kappa = 0.46; 95% CI, 0.40-0.52), with 5% more SD OCT scans demonstrating fluid (P