Title

Does Hypertension Impact 24-Hour Urine Parameters in Patients With Nephrolithiasis?

Publication Date

2015

Journal Title

Urology

Abstract

OBJECTIVE To examine the differences in 24-hour urine parameters and stone composition between patients with and without systemic hypertension (HTN) in a large cohort of stone formers. MATERIALS AND METHODS We performed a retrospective review over a 10-year period of patients with stone, who had completed a 24-hour urinalysis (Litholink) and for whom demographic information was available, including the presence of HTN. Univariate and multivariate analyses were performed, comparing the 24-hour urinalysis profiles of patients with HTN with that of normotensive patients. RESULTS Of the 1115 patients eligible for inclusion, 442 patients (40%) had HTN and 673 (60%) did not. Patients with HTN were significantly older, had a higher body mass index, and had a greater number of comorbid conditions than normotensive patients. Univariate analysis revealed significantly lower urine pH, calcium, supersaturation (SS) of calcium oxalate (CaOx) and SS calcium phosphate (all P < .05) in patients with HTN. Multivariate analysis showed significantly lower calcium, citrate, and SS CaOx in patients with HTN (all P < .05). CONCLUSION Our results demonstrate lower levels of calcium and SS CaOx on univariate and multivariate analysis, as well as lower levels of citrate on multivariate analysis in patients with HTN. These results suggest that lower levels of citrate may contribute to stone formation to a greater degree in patients with HTN than abnormalities in calcium metabolism. (C) 2015 Elsevier Inc.

Volume Number

85

Issue Number

3

Pages

539-543

Document Type

Article

EPub Date

2015/03/04

Status

Faculty; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Urology

PMID

25733263

DOI

10.1016/j.urology.2014.12.013