Title

Nitrogen Bisphosphonate-induced Orbital Inflammatory Disease: Gamma Delta T Cells - A Report and Review of 2 Cases

Publication Date

2014

Journal Title

Ophthal Plast Reconstr Surg

Abstract

With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated cases of orbital inflammation exist in the literature with additional 2 cases reported herein. While the precise triggering mechanism for orbital inflammation is not definitively understood, it appears that a regulatory response from gamma delta T cells is the most likely causative factor. Nitrogen bisphosphonates are a causative agent of orbital inflammatory disease. These case reports adhered to the principles of Helsinki and the Health Insurance Portability and Accountability Act.

Volume Number

30

Issue Number

4

Pages

E84-E85

Document Type

Article

Status

Northwell Researcher

Facility

Northwell Health

Primary Department

Ophthalmology

PMID

24814269

DOI

10.1097/IOP.0b013e31829f3b46