Title

Age-Related Changes in 24-Hour Urine Composition Must be Considered in the Medical Management of Nephrolithiasis

Publication Date

2014

Journal Title

J Endourol

Abstract

Background and Purpose: Over the past 50 years, there has been an upward shift in the age of peak incidence of stone disease, yet less is known regarding how the urinary biochemical profile changes with aging. Therefore, we sought to examine the relationship between age and 24-hour urine composition. Methods: We retrospectively reviewed a database of our tertiary care stone clinic patients seen from March 2002 to February 2012. Analysis of pretreatment 24-hour urine collections across age groups was performed using univariate analysis of variance and multivariate linear regression models adjusting for clinical and demographic factors and 24-hour urine parameters. Results: A total of 1115 patients were broken down into age groups consisting of(221; 19.7%), 45-54.9 years (270; 23.8%), 55-64.9 years (270; 24.6%), and >= 65 years (356; 31.9%). Univariate analysis found significant ascending trends with aging for mean body mass index, while mean urine pH, 24-hour calcium, uric acid (UA), ammonium, creatinine, and supersaturation (SS) of calcium oxalate (CaOx) and calcium phosphate (CaP) decreased with age (all P for trend

Volume Number

28

Issue Number

7

Pages

871-876

Document Type

Article

Status

Faculty; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Urology

PMID

24571654

DOI

10.1089/end.2014.0002