Title

Effects of varying serum glucose levels on F-18-FDG biodistribution

Publication Date

2015

Journal Title

Nucl Med Commun

Abstract

ObjectiveHyperglycemia has been shown to influence fluorine-18 fluorodeoxyglucose (F-18-FDG) uptake in tumor cells. Therefore, patients are instructed to fast for 6h, while maintaining serum glucose levels at an acceptable range. The study was performed to evaluate the effect of fasting blood glucose levels on the biodistribution of F-18-FDG in various tissues including the liver, heart, bone marrow, skeletal muscle, and tumors.Materials and methodsFingerstick fasting blood glucose is routinely measured on the morning of the procedure. The maximum standardized uptake value (SUVmax) in the right and left hepatic lobes, left ventricle, sacrum, thigh, and tumor was measured in 229 consecutive patients undergoing F-18-FDG PET/computed tomography for tumor. Patients were divided into three groups depending on their serum glucose levels: low (

Volume Number

36

Issue Number

7

Pages

717-721

Document Type

Article

Status

Faculty; Northwell Resident; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Radiology

Additional Departments

Orthopedic Surgery

PMID

25888357

DOI

10.1097/mnm.0000000000000319