Publication Date

2015

Journal Title

Evid Based Complement Alternat Med

Abstract

High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.

Volume Number

2015

Pages

456305

Document Type

Article

EPub Date

2015/03/31

Status

Faculty; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Emergency Medicine

Additional Departments

Molecular Medicine; Surgery

PMID

25821489

DOI

10.1155/2015/456305


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