Title
Opioid-induced respiratory depression in the acute care setting: a compendium of case reports
Publication Date
2014
Journal Title
Pain Manag
Abstract
Opioid-induced respiratory depression (OIRD) is a potentially fatal complication of treatment with opioids. Little is known about patient- and case-related factors associated with OIRD. One-hundred-and-five available case reports on OIRD in 134 patients (12 years and older) in the perioperative, obstetric or emergency care setting, published since 1980, were retrieved from the literature. The most frequently reported case-related factors were: morphine use, perioperative setting and obstetrics, neuraxial or intravenous administration. The most frequently reported patient-related factors involved were: female gender, sleep-disordered breathing, obesity, renal impairment, pulmonary disease and CYP450 enzyme polymorphisms. While the analysis has limitations, it confirms that OIRD in the acute setting involves complex and interrelated factors and is a significant cause of preventable morbidity and mortality.
Volume Number
4
Issue Number
4
Pages
317-25
Document Type
Article
EPub Date
2014/10/11
Status
Faculty
Facility
School of Medicine
Primary Department
Anesthesiology
PMID
DOI
10.2217/pmt.14.19
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