Title

EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case

Publication Date

2014

Journal Title

Oral Surg Oral Med Oral Pathol Oral Radiol

Abstract

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.

Volume Number

118

Issue Number

4

Pages

E115-E118

Document Type

Article

EPub Date

2014/04/12

Status

Faculty; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Pathology and Laboratory Medicine

Additional Departments

Dental Medicine

PMID

24721473

DOI

10.1016/j.oooo.2014.02.004