Title

Vitamin K antagonists' use and fracture risk: results from a systematic review and meta-analysis: reply

Publication Date

2016

Journal Title

J Thromb Haemost

Abstract

We thank Zhou and colleagues [1] for their careful reading of our recently published meta-analysis [2] in which we assessed the potential relationship between vitamin K antagonists and bone mineral density as well as fracture risk, and for their thoughtful comments. The authors raise the following five concerns regarding study methodology and data display: multiple testing; potential for type-I error; handling of heterogeneity of results and use of random effects models throughout; method of quality assessment; and data display in forest and funnel plots. This article is protected by copyright. All rights reserved.

Volume Number

14

Issue Number

1

Pages

221-3

Document Type

Article

EPub Date

2015/11/12

Status

Faculty

Facility

School of Medicine

Primary Department

Psychiatry

Additional Departments

Molecular Medicine

PMID

26554746

DOI

10.1111/jth.13180