Title

QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008/2009

Publication Date

2015

Journal Title

Hum Psychopharmacol

Abstract

ObjectiveLittle is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008/2009 and its independent demographic and clinical correlates. MethodData on 3482 hospitalized schizophrenia patients (2004=1826 and 2008/2009=1656) in six Asian countries and territories were collected by either chart review or interviews during a 1-month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure. ResultsThe frequency of QTc prolongation (>456ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008/2009 (p=0.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both p-values

Volume Number

30

Issue Number

2

Pages

94-99

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Psychiatry

Additional Departments

Molecular Medicine

PMID

25611192

DOI

10.1002/hup.2458