Title

Donor information based prediction of early allograft dysfunction and outcome in liver transplantation

Publication Date

2015

Journal Title

Liver International

Abstract

Background & AimsPoor initial graft function was recently newly defined as early allograft dysfunction (EAD) [Olthoff KM, Kulik L, Samstein B, etal. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl 2010; 16: 943]. Aim of this analysis was to evaluate predictive donor information for development of EAD. MethodsSix hundred and seventy-eight consecutive adult patients (mean age 51.6years; 60.3% men) who received a primary liver transplantation (LT) (09/2003-12/2011) were included. Standard donor data were correlated with EAD and outcome by univariable/multivariable logistic regression and Cox proportional hazards to identify prognostic donor factors after adjustment for recipient confounders. Estimates of relevant factors were utilized for construction of a new continuous risk index to develop EAD. Results38.7% patients developed EAD. 30-day survival of grafts with and without EAD was 59.8% and 89.7% (P

Volume Number

35

Issue Number

1

Pages

156-163

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Surgery

Additional Departments

General Internal Medicine

PMID

24351095

DOI

10.1111/liv.12443