Title

Macrophage Migration Inhibitory Factor as a Potential Predictor for Requirement of Renal Replacement Therapy After Orthotopic Liver Transplantation

Publication Date

2015

Journal Title

Liver Transpl

Abstract

Acute kidney injury (AKI) after orthotopic liver transplantation (OLT) is associated with a poor clinical outcome. Because there is no specific treatment for postoperative AKI, early recognition and prevention are fundamental therapeutic approaches. Concentrations of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) are elevated in patients with kidney disease. We hypothesized that plasma MIF concentrations would be greater in patients developing AKI after OLT compared with patients with normal kidney function. Twenty-eight patients undergoing OLT were included in the study. Kidney injury was classified according to AKI network criteria. Fifteen patients (54%) developed severe AKI after OLT, 11 (39%) requiring renal replacement therapy (RRT). On the first postoperative day, patients with severe AKI had greater plasma MIF concentrations (237 +/- 123 ng/mL) than patients without AKI (95 +/- 63 ng/mL; P

Volume Number

21

Issue Number

5

Pages

662-669

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Medicine; Surgery

PMID

25762421

DOI

10.1002/lt.24103