Title

Lesions of the corpus callosum and other commissural fibers: diffusion tensor studies

Publication Date

2014

Journal Title

Semin Ultrasound CT MR

Abstract

The corpus callosum is the largest white matter tract in the brain, connecting the 2 hemispheres. The functions of the corpus callosum are many and varied, and lesions frequently cause only subtle clinical findings. The range of diseases that can affect the corpus callosum is vast and includes all potential white matter disease. The distribution of lesions in the corpus callosum is disease specific in only a few entities such as Susac syndrome and Marchiafava-Bignami disease. Group studies have found significant differences of diffusivity metrics in the corpus callosum in preterm infants, patients suffering seizure activity, and patients with early-onset Alzheimer's disease. Given the challenges that multiple orientation of fibers within the callosum presents, advanced postprocessing methods may be required to reveal ultrastructural disease.

Volume Number

35

Issue Number

5

Pages

445-58

Document Type

Article

EPub Date

2014/09/14

Status

Faculty

Facility

School of Medicine

Primary Department

Radiology

PMID

25217298

DOI

10.1053/j.sult.2014.06.004