Title

In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis

Publication Date

2015

Journal Title

J Magn Reson Imaging

Abstract

BACKGROUND: To apply quantitative whole-brain T1 -rho (T1rho ) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). METHODS: Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T1rho -weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin-lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T2 maps were also acquired. RESULTS: Whole brain white matter (WM) T1rho maps were elevated compared with controls (P = 0.002). WM lesion T1rho and T2 values were highly correlated (r = 0.83), but T1rho demonstrated 25% better contrast to noise ratio (P < 0.001). WM lesion T1rho correlated with disease duration. Gray matter T1rho was negatively correlated with the Expanded Disability Status Scale, r = -0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T1rho , but not on T2 (rT1rho = -0.63, pT1rho = 0.03; rT2 = -0.17, pT2 = 0.6). CONCLUSION: T1rho MRI demonstrates enhanced lesion contrast compared with T2 , and in some cases may provide complementary information. T1rho may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623-1630.

Volume Number

42

Issue Number

6

Pages

1623-30

Document Type

Article

EPub Date

2015/06/03

Status

Faculty

Facility

School of Medicine

Primary Department

Radiology

PMID

26032694

DOI

10.1002/jmri.24954