Publication Date
2015
Journal Title
Leuk Res Rep
Abstract
Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal morbidity and mortality. There is limited published experience regarding therapy of PNH during pregnancy. We describe a case of a 30 year old female with hypoplastic myelodysplastic syndrome and PNH. After two years of treatment with eculizumab, she became pregnant. She developed breakthrough hemolysis at 20 weeks gestation. Pharmacokinetic and pharmacodynamic studies demonstrated a subtherapeutic eculizumab level with absence of complement blockade. Escalation of her eculizumab dose successfully controlled hemolysis and restored therapeutic eculizumab level and activity. She delivered a healthy baby at 36 weeks.
Volume Number
4
Issue Number
1
Pages
36-8
Document Type
Article
EPub Date
2015/06/09
Status
Faculty; Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Hematology/Medical Oncology
Additional Departments
Pediatrics
PMID
DOI
10.1016/j.lrr.2015.05.001