Title

MIF: Mood Improving/Inhibiting Factor?

Publication Date

January 2014

Journal Title

Journal of Neuroinflammation

Abstract

Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particular, macrophage migration inhibitory factor (MIF) has been shown to be significant in depression physiology. In this review we summarize current research on MIF and depression. We highlight the arguments for MIF as a pro-and antidepressant species and discuss the potential implications for therapeutics.

Volume Number

11

Pages

9

Document Type

Article

EPub Date

2014/01/23

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Medicine

PMID

WOS:000333211700002

DOI

10.1186/1742-2094-11-11

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