Title

Modulation of tolerogenic dendritic cells and autoimmunity

Publication Date

January 2014

Journal Title

Semin Cell Dev Biol

Abstract

A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.

Document Type

Article

EPub Date

2014/04/22

Facility

School of Medicine

Primary Department

Molecular Medicine

Additional Departments

Medicine

PMID

24747368

DOI

10.1016/j.semcdb.2014.04.020

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