Title
Establishing a translational genomics infrastructure in pediatric cancer: the GREAT KIDS experience
Publication Date
2015
Journal Title
Per Med
Abstract
We have recently established a biobanking and sequencing pipeline at the University of Chicago dubbed Genomics for Risk Evaluation and Anticancer Therapy in Kids. We plan to intersect family and personal history of cancer and other diseases with multidimensional genomic profiling in order to: understand how genetics may have contributed to the development of cancer for each child, and investigate the spectrum of genomic alterations within a tumor spatially (e.g., primary site vs distant metastasis) and over time (e.g., diagnosis vs relapse). This review highlights some of the practical considerations involved in creating such a program including the capacity to use our platform for multi-institutional collaborations.
Volume Number
12
Issue Number
3
Pages
221-229
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
General Pediatrics
Additional Departments
Molecular Medicine
PMID
DOI
10.2217/pme.14.90
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