Title
A spoonful of sugar helps lymphoma cells go up
Publication Date
2015
Journal Title
Blood
Abstract
In this issue of Blood, Schneider et al(1) document that sugar moieties, introduced into surface-membrane immunoglobulin (smIg) antigen-binding sites on follicular lymphoma (FL) cells by somatic hypermutation (SHM), induce smIg-mediated signals in a distinct, nonstandard manner. This signaling results from the sugar physically interacting with sugar-specific lectins from bacteria. The findings confirm and support the clinical relevance of previous observations about SHM introducing glycans into the variable domains of FL antigen-binding sites,X2-5 and they support the potential importance of microbial exposure to lymphomagenesis and disease progression.
Volume Number
125
Issue Number
21
Pages
3215-3216
Document Type
Article
EPub Date
2015/05/23
Status
Faculty
Facility
School of Medicine
Primary Department
Molecular Medicine
Additional Departments
General Internal Medicine
PMID
DOI
10.1182/blood-2015-04-636209