Title
Proarrhythmic Manifestations of Neuromuscular Dystrophinopathies.
Publication Date
2020
Journal Title
Cardiol Rev
Abstract
Muscular dystrophy has been an elusive term ever since it was first described in the 19 century. Introduced in 1891 by Wilhem Heinrich Erb, muscular dystrophy has been classified as part of a larger group of genetically-determined, progressive degenerative neuromuscular disorders termed "dystrophinopathies." Cardiac arrhythmias may occur during the neurologic course of the disease. Although descriptions of the dystrophinopathies have been reported in the literature, few articles address the use of antiarrhythmic pharmacotherapy in patients with muscular dystrophy. We discuss the pathophysiology of the most common dystrophinopathies, their proarrhythmic sequelae, and the therapeutic use of antiarrhythmic agents in the clinical setting.
Document Type
Article
Status
Faculty; SOM Student
Facility
School of Medicine
Primary Department
Cardiology
PMID
DOI
10.1097/crd.0000000000000305