New Onset Depression among Children, Adolescents, and Adults with Hidradenitis Suppurativa.
BACKGROUND:Information on risk of depression among among children, adolescents and adults with hidradenitis suppurativa (HS) is limited. OBJECTIVE:To compare risk of new-onset depression in HS patients with that of controls. METHODS:Retrospective cohort analysis of 49,280 adult and 3,042 pediatric HS patients and matched controls identified using electronic health records data. Primary outcome was incident depression. RESULTS:Crude incidence rate (IR) was 4.8 per 100 person-years in adult HS patients compared to 3.0 per 100 person-years in controls. Among pediatric patients, crude IR was 4.2 per 100 person-years in HS patients compared with 2.3 per 100 person-years in controls. In adjusted analysis, adults and pediatric patients with HS had a 10% (HR, 1.10; 95% CI, 1.07-1.13; p<0.001) and 26% (HR 1.26; 95% CI 1.10-1.44; p<0.001), respectively, increased risk of developing depression compared to controls. Among HS patients, factors associated with depression included female sex, Caucasian race, smoking, and BMI/obesity in adults and pediatric patients, and substance abuse in adults only. LIMITATIONS:Patients not seeking care in health systems within the database were not captured. CONCLUSION:Children, adolescents and adults with HS are at an increased risk for developing depression, independent of other common risk factors for depression.