Title
Anifrolumab in systemic lupus erythematosus: Current knowledge and future considerations
Publication Date
2020
Journal Title
Immunotherapy
Abstract
© 2020 Future Medicine Ltd. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is potentially life-Threatening and can affect any organ. The complex pathogenesis and heterogeneity of the disease, among other factors, present significant challenges in developing new therapies. Knowledge gained over many years has implicated type I interferon (IFN) in the pathogenesis of SLE and anti-IFN therapies hold promise as a much-needed future treatment for SLE. Anifrolumab, a human monoclonal antibody against the type I IFN receptor, has recently been evaluated in two Phase III clinical trials for the treatment of moderate-To-severe SLE. Here, we review the clinical efficacy and safety of anifrolumab and discuss the potential challenges in determining the optimal SLE patient subgroup for treatment.
Volume Number
12
Issue Number
5
Pages
275 - 286
Document Type
Article
Status
Faculty; Northwell Resident
Facility
School of Medicine; Northwell Health
Primary Department
Rheumatology
PMID
DOI
10.2217/imt-2020-0017
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