SARS-CoV-2 and interferon blockade

B. Diamond, Zucker School of Medicine at Hofstra/Northwell
B. T. Volpe, Zucker School of Medicine at Hofstra/Northwell
S. VanPatten, Northwell Health
Y. Al Abed, Zucker School of Medicine at Hofstra/Northwell

Abstract

© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.