Title

Post-COVID-19 Cholangiopathy: A Novel Entity.

Authors

N. C. Roth, Zucker School of Medicine at Hofstra/NorthwellFollow
A. Kim
T. Vitkovski, Zucker School of Medicine at Hofstra/NorthwellFollow
J. Xia, Zucker School of Medicine at Hofstra/NorthwellFollow
G. Ramirez
D. Bernstein, Zucker School of Medicine at Hofstra/NorthwellFollow
J. M. Crawford, Zucker School of Medicine at Hofstra/NorthwellFollow

Publication Date

2021

Journal Title

Am J Gastroenterol

Abstract

Introduction

Liver chemistry abnormalities are a frequent manifestation of coronavirus disease 2019 (COVID-19) but are usually transient and resolve with disease resolution.

Methods

We describe the clinical course and histologic features of 3 adults who developed prolonged and severe cholestasis during recovery from critical cardiopulmonary COVID-19.

Results

These patients had clinical and histologic features similar to secondary sclerosing cholangitis of the critically ill patient, but with unique histologic features including severe cholangiocyte injury and intrahepatic microangiopathy suggestive of direct hepatic injury from COVID-19.

Discussion

We believe that these cases constitute a novel severe post-COVID-19 cholangiopathy with potential for long-term hepatic morbidity.

Document Type

Article

Status

Faculty; Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Hepatology

Additional Departments

Pathology and Laboratory Medicine; Science Education; COVID-19 Publications

PMID

33464757

DOI

10.14309/ajg.0000000000001154