Title
Influence of polyunsaturated fatty acids on urologic inflammation
Publication Date
2015
Journal Title
Int Urol Nephrol
Abstract
PURPOSE: Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity. METHODS: This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome. RESULTS: The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs. CONCLUSIONS: The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.
Volume Number
47
Issue Number
11
Pages
1753-61
Document Type
Article
EPub Date
2015/09/29
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Urology
PMID
DOI
10.1007/s11255-015-1108-8