Publication Date

2014

Journal Title

Leukemia

Abstract

DNMT3B encodes a DNA methyltransferase implicated in aberrant epigenetic changes contributing to leukemogenesis. We tested whether DNMT3B expression, measured by NanoString nCounter assay, associates with outcome, gene and microRNA expression and DNA methylation profiles in 210 older (60 years) adults with primary, cytogenetically normal acute myeloid leukemia (CN-AML). Patients were dichotomized into high versus low expressers using median cut. Outcomes were assessed in the context of known CN-AML prognosticators. Gene and microRNA expression, and DNA methylation profiles were analyzed using microarrays and MethylCap-sequencing, respectively. High DNMT3B expressers had fewer complete remissions (CR; P=0.002) and shorter disease-free (DFS; P=0.02) and overall (OS; P

Volume Number

29

Issue Number

3

Pages

567-575

Document Type

Article

EPub Date

2014/09/11

Status

Faculty

Facility

School of Medicine

Primary Department

Hematology/Medical Oncology

PMID

25204569

DOI

10.1038/leu.2014.267


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