Publication Date
2014
Journal Title
Clin J Am Soc Nephrol
Abstract
Membranoproliferative GN represents a pattern of injury seen on light microscopy. Historically, findings on electron microscopy have been used to further subclassify this pathologic entity. Recent advances in understanding of the underlying pathobiology have led to a proposed classification scheme based on immunofluorescence findings. Dysregulation of the complement system has been shown to be a major risk factor for the development of a membranoproliferative GN pattern of injury on kidney biopsy. Evaluation and treatment of this complex disorder rest on defining the underlying mechanisms.
Volume Number
9
Issue Number
3
Pages
600-608
Document Type
Article
EPub Date
2014/01/11
Status
Faculty
Facility
School of Medicine
Primary Department
Nephrology
PMID
DOI
10.2215/cjn.06410613