Probiotics: The Next Step in UTI Prevention?
AAP Grand Rounds
Source: Lee SJ, Lee JW. Probiotics prophylaxis in infants with primary vesicoureteral reflux. Pediatr Nephrol. 2015; 30( 4): 609– 613; doi: 10.1007/s00467-014-2988-zOpenUrlCrossRefMedlinePICOQuestion: Among children aged 1 week to 12 months with primary vesicoureteral reflux, what is the incidence of recurrent urinary tract infection with probiotic prophylaxis compared to antibiotic prophylaxis?Question type: InterventionStudy type: Randomized trialInvestigators from South Korea conducted a prospective randomized trial of antibiotic versus probiotic prophylaxis for prevention of recurrent urinary tract infection (UTI) in children with primary vesicoureteral reflux (VUR). Children were eligible to participate if they were aged 1 week to 12 months and had primary VUR diagnosed by voiding cystourethrography (VCUG) after a first febrile UTI during the study period from 2004–2008. Those with reflux associated with other underlying structural abnormality such as dysplasia were excluded. Participants were randomized to either a probiotic group, …
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