Publication Date
2018
Journal Title
World J Gastroenterol
Abstract
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Antiintegrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels. Natalizumab, which acts on α4integrin, was the first such drug to be approved for Crohn’s disease, but its use is limited due to the risk of progressive multifocal leukoencephalopathy. Vedolizumab produces few systemic adverse effects because it acts on guttrophic α4β7 integrin, and has been approved and is being used to treat IBD. Currently, several antiintegrin drugs, including etrolizumab, which acts on β7integrin, and PF00547569, which targets mucosal addressin cell adhesion molecule1, are undergoing clinical trials and the results are being closely watched.
Volume Number
24
Issue Number
17
Pages
1868 - 1880
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
Ophthalmology
PMID
DOI
10.3748/wjg.v24.i17.1868