Submissions from 2021
Development and Validation of a Machine learning prediction model of respiratory failure within 48 hours of patient admission for COVID-19., S. Bolourani, M. Brenner, P. Wang, T. McGinn, J. Hirsch, D. Barnaby, and T. Zanos
Prevalence and Predictors of Venous Thromboembolism or Mortality in Hospitalized COVID-19 Patients., S. L. Cohen, E. Gianos, M. A. Barish, S. Chatterjee, N. Kohn, M. Lesser, D. Giannis, K. Coppa, J. Hirsch, T. McGinn, M. Goldin, and A. Spyropoulos
Potential Impact of Delay in Cancer Screening due to COVID-19., M. I. Ehrlich and M. W. Saif
Submissions from 2020
Video or Telephone? A Natural Experiment on the Added Value of Video Communication in Community Paramedic Responses, K. A. Abrashkin, J. D. Washko, T. Li, J. Berkowitz, A. Poku, J. Zhang, K. L. Smith, and K. V. Rhodes
Acute, Post-Acute, and Primary Care Utilization in a Home-Based Primary Care Program during COVID-19., K. A. Abrashkin, J. Zhang, and A. Poku
DO NOT FALL to the VAPE TRAP!, S. Acharya, S. I. Ali, S. Anwar, and A. Glaser
Anodal block permits directional vagus nerve stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, and S. Zanos
Access and Continuity: A Multidisciplinary Education Workshop to Teach Patient-Centered Medical Home (PCMH) Principles, L. Block, C. Petersen, D. J. Coletti, P. Yalakkishettar, and N. LaVine
Using machine learning to predict early readmission following esophagectomy, S. Bolourani, M. A. Tayebi, L. Diao, P. Wang, V. Patel, F. Manetta, and P. C. Lee
Predicting respiratory failure after pulmonary lobectomy using machine learning techniques, S. Bolourani, P. Wang, V. M. Patel, F. Manetta, and P. C. Lee
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory, K. Chan, J. Nestor, T. S. Huerta, N. Certain, G. Moody, C. Kowal, P. T. Huerta, B. T. Volpe, B. Diamond, and L. P. Wollmuth
The Longitudinal Immune Response to Coronavirus Disease 2019: Chasing the Cytokine Storm., A. S. Chau, A. G. Weber, N. I. Maria, S. Narain, A. Liu, N. Hajizadeh, P. Malhotra, O. Bloom, G. Marder, and B. Kaplan
Vemurafenib-induced pancreatitis in a patient with recurrent hairy cell leukaemia., S. Y. Chung, J. G. Shen, and C. M. Ghiuzeli
Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis, A. J. Darzi, S. G. Karam, R. Charide, I. Etxeandia-Ikobaltzeta, M. Cushman, M. K. Gould, L. Mbuagbaw, F. A. Spencer, A. C. Spyropoulos, H. J. Schunemann, and +9 additional authors
Examining the Causes and Consequences of Increasing Insulin Costs With Prospective Interventions, M. Dawkins, T. Menon, and A. K. Myers
Machine learning to assist clinical decision-making during the COVID-19 pandemic., S. Debnath, D. P. Barnaby, K. Coppa, A. Makhnevich, E. J. Kim, S. Chatterjee, V. Tóth, T. J. Levy, M. D. Paradis, S. L. Cohen, J. S. Hirsch, T. P. Zanos, and Northwell COVID-19 Research Consortium
An Economic Evaluation of Over 200,000 Revision Total Hip Arthroplasties: Is the Current Model Sustainable?, W. DeGouveia, H. S. Salem, N. Sodhi, H. K. Ani, R. Vakharia, Z. Chen, M. W. Roche, and M. A. Mont
Coronavirus Disease 2019 (COVID-19)-Related Multisystem Inflammatory Syndrome in a Pregnant Woman., M. Gulersen, C. Staszewski, E. Grayver, H. Tam Tam, E. Gottesman, D. Isseroff, B. Rochelson, and C. Bonanno
Coronavirus Disease 2019 (COVID-19)-Related Multisystem Inflammatory Syndrome in a Pregnant Woman., M. Gulersen, C. Staszewski, E. Grayver, H. Tam Tam, E. Gottesman, D. Isseroff, B. Rochelson, and C. Bonanno
Significance of Multiple Adverse Social Determinants of Health on the Diagnosis, Control, and Management of Diabetes, E. J. Kim, S. Abrahams, L. Marrast, J. Martinez, A. D. Hanchate, and J. Conigliaro
Prevalence of Social Determinants of Health and Associations of Social Needs Among United States Adults, 2011-2014, E. J. Kim, S. Abrahams, O. Uwemedimo, and J. Conigliaro
EDA2R mediates podocyte injury in high glucose milieu, X. Lan, V. Kumar, A. Jha, R. Aslam, H. Wang, K. Chen, Y. Yu, W. He, A. Malhotra, P. C. Singhal, and +2 additional authors
After ASPREE: Assessing Aspirin Usage in Older Adults Using an Interprofessional Approach, N. A. LaVine, V. Zhao, D. J. Coletti, J. Verbsky, and L. Block
Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019-Induced Vasodilatory Shock: A Retrospective Matched Cohort Study., D. E. Leisman, F. Mastroianni, G. Fisler, S. Shah, Z. Hasan, M. Narasimhan, M. D. Taylor, and C. S. Deutschman
HMGB1 in Systemic Lupus Erythematosus, T. Liu, M. Son, and B. Diamond
Effect of Direct Oral Anticoagulant, Patient, and Surgery Characteristics on Clinical Outcomes in the Perioperative Anticoagulation Use for Surgery Evaluation Study., K. MacDougall, J. D. Douketis, N. Li, N. P. Clark, A. Tafur, J. D'Astous, J. Duncan, S. Schulman, and A. C. Spyropoulos
New Paradigms of Extended Thromboprophylaxis in Medically Ill Patients, K. MacDougall and A. C. Spyropoulos
Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy, N. I. Maria and A. Davidson
Treatment Complications of Atrial Fibrillation and Their Management, A. Mattia, J. Newman, and F. Manetta
An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients., V. Nair, J. S. Hirsch, M. Abate, S. K. Satapathy, S. J. Miyara, A. M. Kressel, A. Xiang, G. Wu, S. D. Butensky, D. Lin, S. Williams, M. C. Bhaskaran, D. T. Majure, E. Grodstein, L. Lau, G. Nair, A. E. Fahmy, I. Berlinrut, L. B. Becker, and P. Malhotra
Management of Iron-Deficiency Anemia on Inpatients and Appropriate Discharge and Follow-Up., K. Patel, Z. Memon, and R. Mazurkiewicz
Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, and +6 additional authors
Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, and +6 additional authors
Rapid Emergence of SARS-CoV-2 in the Greater New York Metropolitan Area: Geolocation, Demographics, Positivity Rates, and Hospitalization for 46,793 Persons Tested by Northwell Health., S. B. Reichberg, P. P. Mitra, A. Haghamad, G. Ramrattan, J. M. Crawford, G. J. Berry, K. W. Davidson, A. Drach, S. Duong, S. Juretschko, N. I. Maria, Y. Yang, Y. C. Ziemba, and Northwell COVID-19 Research Consortium
Prognostic Molecular Signatures for Metastatic Potential in Clinically Low-Risk Stage I and II Clear Cell Renal Cell Carcinomas, A. J. Shih, N. Murphy, Z. Kozel, O. Yaskiv, A. Liew, L. Kavoussi, S. Hall, M. Vira, X. Zhu, A. T. Lee, and +2 additional authors
Multifocal extracranial mycotic aneurysms in a patient with endocarditis, A. M. Spring, M. A. Catalano, B. F. Farber, K. V. Krishnasastry, and P. J. Yu
Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19., A. C. Spyropoulos, J. H. Levy, W. Ageno, J. M. Connors, B. J. Hunt, T. Iba, M. Levi, C. M. Samama, D. Giannis, and +2 additional authors
Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19., AC Spyropoulos, JH Levy, W Ageno, JM Connors, BJ Hunt, T Iba, M Levi, CM Samama, D Giannis, JD Douketis, and +1 additional author
Predictors of Bleeding in the Perioperative Anticoagulant Use for Surgery Evaluation Study, A. J. Tafur, N. P. Clark, A. C. Spyropoulos, N. Li, E. Kaplovitch, K. MacDougall, S. Schulman, J. A. Caprini, and J. Douketis
Submissions from 2019
Sleep and Environmental Factors Affecting Glycemic Control in People with Type 2 Diabetes Mellitus, A. Afroz-Hossain, M. Dawkins, and A. K. Myers
Small Septal Branch Artery Thrombus Inducing Ventricular Fibrillation: To Intervene or Not to Intervene, V. Agarwal, P. C. Olson, J. Mroue, Y. Olkovsky, S. Bekheit, and J. Lafferty
A case of dolutegravir-induced cutaneous small vessel vasculitis, B. S. Bennett, N. Mikaberidze, and L. M. Ahmadi
Incidence of Acute Kidney Injury in Patients with Chronic Renal Insufficiency: Transcatheter versus Surgical Aortic Valve Replacement, M. Catalano, D. Lin, H. Cassiere, N. Kohn, B. Rutkin, G. Maurer, J. A. Berg, R. Esposito, A. Hartman, P. Yu, and +1 additional author
Marked multi-distribution myocardial ischemia in a patient with hypertrophic cardiomyopathy and no obstructive coronary artery disease, N. Chan, V. Kataria, J. Delphin, A. Auerbach, and J. N. Makaryus
Attitudes of Physicians to Recording Clinical Encounters: Responses to an Online Survey, A. Joshi, M. Farberov, S. Demissie, M. C. Smith, and G. Elwyn
Improving provider adoption with adaptive clinical decision support surveillance: An observational study, S. Khan, S. Richardson, A. Liu, V. Mechery, L. McCullagh, A. Schachter, S. Pardo, and T. McGinn
Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation, K. R. Lehner, H. A. Silverman, M. E. Adorissio, A. Roy, A. Al-Onaizi, S. S. Chavan, Y. Al-Abed, C. N. Metz, K. J. Tracey, V. A. Paviov, and +6 additional authors
HMGB1-C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis., T. Liu, A. Xiang, T. Peng, A. C. Doran, J. Tracey, Z. J. Barnes, I. Tabas, M. Son, and B. Diamond
Monocytopenia in clozapine-induced agranulocytosis: Insights into pathophysiology and treatment, R. Patel, A. Lima, C. Burke, and M. Hoffman
The Clinical Utility of Epicutaneous Immunotherapy for Peanut Allergy, M. Samstein and P. Ponda
Large-Scale Validation of the Paddling Pool Task in the Clockmaze for Studying Hippocampus-Based Spatial Cognition in Mice, R. Sankowski, T. S. Huerta, R. Kalra, T. J. Klein, J. Strohl, A. Al-Abed, S. Robbiati, and P. T. Huerta
Chronic lymphocytic leukemia (CLL) treatment: So many choices, such great options, S. Sharma and K. R. Rai
Identifying the barriers and perceptions of non-Hispanic black and Hispanic/Latino persons with uncontrolled type 2 diabetes for participation in a home Telemonitoring feasibility study: a quantitative analysis of those who declined participation, withdrew or were non-adherent, T. Tong, A. K. Myers, A. A. Bissoonauth, R. Pekmezaris, and A. Kozikowski
Management of the neck after definitive chemoradiation in patients with HPV-associated oropharyngeal cancer: An institutional experience, M. Wotman, M. Ghaly, L. Massaro, T. Tham, N. Seetharamu, D. Kamdar, D. Frank, D. Kraus, and S. Teckie
Prosthetic Valve Legionella Endocarditis, J. S. Young, B. F. Farber, S. S. Pupovac, and L. M. Graver
Risk stratification for nonagenarians undergoing transcatheter aortic valve replacement, P-J. Yu, M. Catalano, R. Palazzo, H. Cassiere, N. Kohn, B. Rutkin, G. Maurer PA, J. A. Berg, and A. Hartman
Predictors of Increased Length of Hospital Stay in Patients with Severe Cardiomyopathy Undergoing Coronary Artery Bypass Grafting, P. Yu, D. Lin, M. Catalano, H. Cassiere, N. Kohn, and A. Hartman
Impact of novel oral anticoagulants vs warfarin on effusions after coronary artery bypass grafting, P. Yu, D. Lin, M. Catalano, H. Cassiere, F. Manetta, N. Kohn, and A. Hartman
Submissions from 2018
Successful pulmonary thromboendarterectomy in a patient with sickle cell disease and associated resolution of a leg ulcer, A. Agrawal, R. Shah, M. D. Bacchetta, and A. Talwar
B-1a cells protect mice from sepsis-induced acute lung injury, M. Aziz, Y. Ode, M. Zhou, M. Ochani, N. E. Holodick, T. L. Rothstein, and P. Wang
Sudden cardiac death in isolated right ventricular hypertrabeculation/noncompaction cardiomyopathy, S. Bekheit, B. Karam, F. Daneshvar, J. Zaidan, R. Tabet, J. Spagnola, and J. Lafferty
Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects, J. Calise, S. M. Renteria, P. K. Gregersen, and B. Diamond
Smoking and alcohol drinking effect on radiotherapy associated risk of second primary cancer and mortality among breast cancer patients, P. DiMarzio, R. Peila, O. Dowling, D. M. Timony, A. Balgobind, L. N. Lee, K. M. Kostroff, and G. Y. F. Ho
Direct oral anticoagulants in the treatment of pulmonary embolism, J. B. Eldredge and A. C. Spyropoulos
A Mixed-Methods Approach to Humanistic Interprofessional Faculty Development., A. Fornari, L. M. Tortez, M. Lay, B. Hirsch, D. Tanzi, I. Friedman, A. P. Ricardo, R. Pekmezaris, and W. Branch
Reversal of Anticoagulation: Therapeutic Advances and Clinical Guidelines, M. Goldin, G. J. Hughes, Z. Choudhary, S. Tariq, H. Shafeeq, and J. Cohen
Ventilator Weaning and Excursion Time Index: One Step Closer to the Quantum Leap?, E. Gottesman, A. Palkar, and H. Greenberg
Immunization Elicits Antigen-Specific Antibody Sequestration in Dorsal Root Ganglia Sensory Neurons, M. Gunasekaran, P. K. Chatterjee, A. Shih, G. H. Imperato, G. Kumar, A. Lee, C. Bouton, B. Sherry, B. Diamond, T. R. Coleman, C. N. Metz, K. J. Tracey, S. S. Chavan, and +9 additional authors
Persons with Chronic Spinal Cord Injury Have Decreased Natural Killer Cell and Increased Toll-Like Receptor/Inflammatory Gene Expression, P. Herman, A. Stein, K. Gibbs, I. Korsunsky, P. Gregersen, and O. Bloom
ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation., U. Ibrahim, A. Saqib, M. Rehan, and J. P. Atallah
Follicular helper T cells in systemic lupus erythematosus, S. J. Kim, K. Lee, and B. Diamond
High-mobility group box 1-induced complement activation causes sterile inflammation, S. Y. Kim, M. Son, S. E. Lee, I. H. Park, M. S. Kwak, M. Han, H. S. Lee, E. S. Kim, B. Diamond, J. S. Shin, and +3 additional authors
Establishing Surrogate Kidney Endpoints for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes., M. Mackay, M. Dall'Era, J. Fishbein, K. Kalunian, M. Lesser, J. Sanchez Guerrero, D. M. Levy, E. Silverman, M. Petri, B. H. Rovin, and +19 additional authors
Mutations of recombinant aquaporin-4 antibody in the Fc domain can impair complement-dependent cellular cytotoxicity and transplacental transport, S. Mader, L. Brimberg, J. N. Soltys, J. L. Bennett, and B. Diamond
Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder, S. Mader, V. Jeganathan, Y. Arinuma, Y. Fujieda, I. Dujmovic, J. Drulovic, J. N.H. Stern, C. Aranow, M. Mackay, B. Diamond, and +5 additional authors
Opiate Prescribing in Hospitalized Older Adults: Patterns and Outcomes., S. Maiti, L. Sinvani, A. Kozikowski, V. Patel, M. Akerman, K. Patel, C. Nouryan, G. Qiu, R. Pekmezaris, G. Wolf-Klein, and +2 additional authors
Plasma Cell Differentiation Pathways in Systemic Lupus erythematosus, S. Malkiel, A. N. Barlev, Y. Atisha-Fregoso, J. Suurmond, and B. Diamond
Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases, P. Manu, Y. Lapitskaya, A. Shaikh, and J. Nielsen
Valve in valve transcatheter aortic valve implantation (ViV-TAVI) versus redo-Surgical aortic valve replacement (redo-SAVR): A systematic review and meta-analysis, N. Nalluri, A. B. Munir, B. Karam, D. Asti, J. Spagnola, E. Barsoum, G. A. Maniatis, F. Tamburrino, R. Kandov, J. Lafferty, C. Kliger, and +7 additional authors
Periprocedural Outcomes of Direct Oral Anticoagulants Versus Warfarin in Nonvalvular Atrial Fibrillation: Meta-Analysis of Phase III Trials, B. Nazha, B. Pandya, J. Cohen, M. Zhang, R. D. Lopes, D. A. Garcia, M. W. Sherwood, and A. C. Spyropoulos
Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors, J. Nestor, Y. Arinuma, T. S. Huerta, C. Kowal, E. Nasiri, N. Kello, Y. Fujieda, P. T. Huerta, B. T. Volpe, B. Diamond, and +4 additional authors
Takotsubo Cardiomyopathy precipitated by opiate withdrawal, P. C. Olson, V. Agarwal, J. C. Lafferty, and S. Bekheit
Do-Not-Resuscitate Orders in Older Adults During Hospitalization: A Propensity Score-Matched Analysis., K. Patel, L. Sinvani, V. Patel, A. Kozikowski, C. Smilios, M. Akerman, K. Kiszko, S. Maiti, Gisele Wolf-Klein, R. Pekmezaris, and +1 additional author
Hypoglycemia and Sudden Death During Treatment With Methadone for Opiate Detoxification, C. J. Plescia and P. Manu
Constitutive vagus nerve activation modulates immune suppression in sepsis survivors, M. Rana, Y. Fei-Bloom, M. Son, A. L. Bella, M. Ochani, Y. A. Levine, P. Y. Chiu, P. Wang, S. S. Chavan, B. T. Volpe, B. Sherry, and B. Diamond
Unusual case of dasatinib-associated acute bilateral hyphemas leading to blindness in a patient with chronic myeloid leukaemia, S. Sharma, N. Garg, and C. M. Ghiuzeli
Targeting DEC-205(-)DCIR2(+) dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis, I. Tabansky, D. B. Keskin, D. Watts, C. Petzold, M. Funaro, W. Sands, P. Wright, S. Najjar, B. Diamond, J. N. H. Stern, and +4 additional authors
Analysis of menstrual effluent: diagnostic potential for endometriosis, L. A. Warren, A. Shih, S. M. Renteira, T. Seckin, B. Blau, K. Simpfendorfer, C. N. Metz, and P. K. Gregersen
Submissions from 2017
Using Objective Structured Teaching Encounters (OSTEs) to prepare chief residents to be emotionally intelligent leaders, S. A. Cerrone, P. Adelman, S. Akbar, A. C. Yacht, and A. Fornari
Survival Benefit and Cost Savings From Compliance With a Simplified 3-Hour Sepsis Bundle in a Series of Prospective, Multisite, Observational Cohorts, D. E. Leisman, M. E. Doerfler, M. F. Ward, K. D. Masick, B. J. Wie, J. L. Gribben, E. Hamilton, Z. Klein, Andrea R. Bianculli, M. B. Akerman, J. K. D'Angelo, and J. A. D'Amore
Submissions from 2016
Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential, J. Bloom, C. Metz, S. Nalawade, J. Casabar, K. Fan Cheng, M. He, B. Sherry, T. Coleman, T. Forsthuber, and Y. Al-Abed
BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia, S. S. Chen, B. Y. Chang, S. Chang, T. Tong, S. Ham, B. Sherry, J. A. Burger, K. R. Rai, and N. Chiorazzi
Pomalidomide reverses gamma-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors, B. M. Dulmovits, A. O. Appiah-Kubi, J. Papoin, M. He, Y. Al-Abed, S. Didier, M. Gould, S. Husain-Krautter, S. A. Singh, A. Vlachos, S. L. Allen, J. M. Lipton, J. M. Liu, L. Blanc, and +7 additional authors
Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma, D. Markowitz, C. Powell, N. L. Tran, M. E. Berens, T. C. Ryken, L. Rosen, S. Sun, M. Symons, Y. Al-Abed, R. Ruggieri, and +2 additional authors
Type VI Choledochal Cyst—An Unusual Presentation of Jaundice, L. Nambiar, E. Siskind, A. W. Shen, C. Fan, G. Grimaldi, C. Choy, J. Madariaga, J. Nicastro, E. P. Molmenti, G. Coppa, and +1 additional author
Immune-mediated Brain Pathology: From Autoantibodies to Microglia, J. Nestor, A. Gata-Garcia, Y. Arinuma, Y. Fujieda, C. Kowal, and B. Diamond
Submissions from 2015
A Case of Phaeohyphomycosis Caused by Exophiala oligosperma in a Renal Transplant Patient Successfully Treated with Posaconazole, A. C. Levy, S Rehman, D.A. Sutton, K.I. Burris, D.A. Hirschwerk, N.P. Wiederhold, J. Lindner, M. Bhaskaran, H.L. Rilo, E.P. Molmenti, and +3 additional authors
HMGB1 mediates anemia of inflammation in murine sepsis survivors, S. I. Valdes-Ferrer, J. Papoin, M. E. Dancho, L. P. S. Olofsson, J. Li, J. M. Lipton, P. Avancena, H. Yang, Y. R. Zou, S. S. Chavan, B. T. Volpe, S. Rivella, B. Diamond, B. M. Steinberg, L. Blanc, K. J. Tracey, and +2 additional authors
Defects in germinal center selection in SLE, M. Woods, Y. R. Zou, and A. Davidson
Submissions from 2014
MIF: Mood Improving/Inhibiting Factor?, J. Bloom and Y. Al-Abed