Publication Date

2016

Journal Title

Cancers (Basel)

Abstract

Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation.

Volume Number

8

Issue Number

4

Pages

E42

Document Type

Article

Status

Faculty; Northwell Resident

Facility

School of Medicine; Northwell Health

Primary Department

Radiation Medicine

Additional Departments

Molecular Medicine; Neurosurgery

PMID

27043632

DOI

10.3390/cancers8040042


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