Retinal pigment epithelial tear after intravitreal aflibercept for neovascular age-related macular degeneration
Ophthalmic Surg Lasers Imaging Retina
Two eyes with neovascular age-related macular degeneration and a suboptimal response to intravitreal ranibizumab and bevacizumab developed tears after being switched to intravitreal aflibercept, a drug with enhanced binding characteristics to vascular endothelial growth factor. Both eyes had sub-retinal pigment epithelium (RPE) choroidal neovascularization adherent to the back surface of the RPE in the fibrovascular RPE detachment that showed increased contracture of the fibrovascular tissue following the use of aflibercept. The driving force to develop the tears may be related to the recently described angiofibrotic switch, which is governed by the ration of connective tissue growth factor to vascular endothelial growth factor.
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