Title
Lesions of the corpus callosum and other commissural fibers: diffusion tensor studies
Publication Date
2014
Journal Title
Semin Ultrasound CT MR
Abstract
The corpus callosum is the largest white matter tract in the brain, connecting the 2 hemispheres. The functions of the corpus callosum are many and varied, and lesions frequently cause only subtle clinical findings. The range of diseases that can affect the corpus callosum is vast and includes all potential white matter disease. The distribution of lesions in the corpus callosum is disease specific in only a few entities such as Susac syndrome and Marchiafava-Bignami disease. Group studies have found significant differences of diffusivity metrics in the corpus callosum in preterm infants, patients suffering seizure activity, and patients with early-onset Alzheimer's disease. Given the challenges that multiple orientation of fibers within the callosum presents, advanced postprocessing methods may be required to reveal ultrastructural disease.
Volume Number
35
Issue Number
5
Pages
445-58
Document Type
Article
EPub Date
2014/09/14
Status
Faculty
Facility
School of Medicine
Primary Department
Radiology
PMID
DOI
10.1053/j.sult.2014.06.004