Publication Date

2015

Journal Title

Leuk Res Rep

Abstract

Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal morbidity and mortality. There is limited published experience regarding therapy of PNH during pregnancy. We describe a case of a 30 year old female with hypoplastic myelodysplastic syndrome and PNH. After two years of treatment with eculizumab, she became pregnant. She developed breakthrough hemolysis at 20 weeks gestation. Pharmacokinetic and pharmacodynamic studies demonstrated a subtherapeutic eculizumab level with absence of complement blockade. Escalation of her eculizumab dose successfully controlled hemolysis and restored therapeutic eculizumab level and activity. She delivered a healthy baby at 36 weeks.

Volume Number

4

Issue Number

1

Pages

36-8

Document Type

Article

EPub Date

2015/06/09

Status

Faculty, Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Hematology/Medical Oncology

Additional Departments

Pediatrics

PMID

26052501

DOI

10.1016/j.lrr.2015.05.001


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