Publication Date
2014
Journal Title
World J Gastrointest Pharmacol Ther
Abstract
Methotrexate has been used an immunomodulator in many autoimmune diseases, including inflammatory bowel disease. However, many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios: (1) steroid dependant Crohn's disease (CD); (2) maintenance of remission in steroid free CD; (3) azathioprine failures in CD; (4) in combination therapy with Anti-TNF agents in CD; (5) decreasing antibody formation to Anti-TNF therapy in CD; (6) management of fistulizing disease in CD; and (7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients.
Volume Number
5
Issue Number
3
Pages
113-21
Document Type
Article
EPub Date
2014/08/19
Status
Faculty
Facility
School of Medicine
Primary Department
Gastroenterology
PMID
DOI
10.4292/wjgpt.v5.i3.113