Title

Inherited disorders of bilirubin clearance

Publication Date

January 2015

Journal Title

Pediatr Res

Abstract

Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (Dubin-Johnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome). In this review, the molecular mechanisms and clinical manifestations of these conditions are described, as well as current approaches to diagnosis and therapy.Pediatric Research (2015); doi:10.1038/pr.2015.247.

Document Type

Article

EPub Date

2015/11/26

Facility

School of Medicine

Primary Department

Pediatrics

PMID

26595536

DOI

10.1038/pr.2015.247

This document is currently not available here.


Share

COinS