"Transjugular intrahepatic portosystemic shunt creation for cirrhotic p" by J. Merola, B. E. Fortune et al.
 

Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis.

Publication Date

2018

Journal Title

Eur J Gastroenterol Hepatol

Abstract

BACKGROUND: Portal vein thrombosis (PVT) develops in cirrhotic patients because of stagnation of blood flow. Transjugular intrahepatic portosystemic shunt (TIPS) creates a low-resistance conduit that restores portal venous patency and blood flow.

AIM: The effect of PVT on transplant-free survival in cirrhotic patients undergoing TIPS creation was evaluated.

PATIENTS AND METHODS: A multicenter, retrospective cohort study of patients who underwent TIPS creation for cirrhotic portal hypertension was carried out. A Cox model with propensity score adjustment was developed to evaluate the effect of PVT on 90-day and 3-year transplant-free survival. A subgroup analysis examining mortality of those with superior and inferior PVT was also carried out.

RESULTS: A total of 252 consecutive TIPS creations were assessed, including 65 in patients with PVT. Survival of patients with high Model for End-stage Liver Disease scores (≥18) and PVT was not statistically different compared with patients with low Model for End-stage Liver Disease scores (

CONCLUSION: The presence of PVT does not impair the prognosis of patients following TIPS creation, particularly in patients with superior portal occlusion.

Volume Number

30

Issue Number

6

Pages

668-675

Document Type

Article

Status

Faculty

Facility

School of Medicine

Primary Department

Surgery

Additional Departments

General Internal Medicine

PMID

29462027

DOI

10.1097/MEG.0000000000001097

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