Publication Date
2018
Journal Title
Glob Cardiol Sci Pract
Abstract
Macrophage migration inhibitory factor (MIF) has been described as a pro-inflammatory cytokine and regulator of neuro-endocrine function. It plays an important upstream role in the inflammatory cascade by promoting the release of other inflammatory cytokines such as TNF-alpha and IL-6, ultimately triggering a chronic inflammatory immune response. As lungs can synthesize and release MIF, many studies have investigated the potential role of MIF as a biomarker in assessment of patients with pulmonary arterial hypertension (PAH) and using anti-MIFs as a new therapeutic modality for PAH.
Volume Number
2018
Issue Number
2
Document Type
Article
Status
Faculty
Facility
School of Medicine
Primary Department
General Pediatrics
Additional Departments
Endocrinology, Diabetes, and Metabolism; Molecular Medicine; Surgery
PMID
DOI
10.21542/gcsp.2018.14
