Vitamin K antagonists' use and fracture risk: results from a systematic review and meta-analysis: reply
J Thromb Haemost
We thank Zhou and colleagues  for their careful reading of our recently published meta-analysis  in which we assessed the potential relationship between vitamin K antagonists and bone mineral density as well as fracture risk, and for their thoughtful comments. The authors raise the following five concerns regarding study methodology and data display: multiple testing; potential for type-I error; handling of heterogeneity of results and use of random effects models throughout; method of quality assessment; and data display in forest and funnel plots. This article is protected by copyright. All rights reserved.
School of Medicine