External validation of a risk assessment model for venous thromboembolism in the hospitalised acutely-ill medical patient (VTE-VALOURR)
Venous thromboembolic (VTE) risk assessment remains an important issue in hospitalised, acutely-ill medical patients, and several VTE risk assessment models (RAM) have been proposed. The purpose of this large retrospective cohort study was to externally validate the IMPROVE RAM using a large database of three acute care hospitals. We studied 41,486 hospitalisations (28,744 unique patients) with 1,240 VTE hospitalisations (1,135 unique patients) in the VIE cohort and 40,246 VIE-free hospitalisations (27,609 unique patients) in the control cohort. After chart review, 139 unique VIE patients were identified and 278 randomly-selected matched patients in the control cohort. Seven independent VIE risk factors as part of the RAM in the derivation cohort were identified. In the validation cohort, the incidence of VIE was 0.20%; 95% confidence interval (CI) 0.18-0.22, 1.04%; 95%CI 0.88-1.25, and 4.15%; 95%CI 2.79-8.12 in the low, moderate, and high VIE risk groups, respectively, which compared to rates of 0.45%, 1.3%, and 4.74% in the three risk categories of the derivation cohort. For the derivation and validation cohorts, the total percentage of patients in low, moderate and high VIE risk occurred in 68.6% vs 63.3%, 24.8% vs 31.1%, and 6.5% vs 5.5%, respectively. Overall, the area under the receiver-operator characteristics curve for the validation cohort was 0.7731. In conclusion, the IMPROVE RAM can accurately identify medical patients at low, moderate, and high VIE risk. This will tailor future thromboprophylactic strategies in this ' population as well as identify particularly high VIE risk patients in whom multimodal or more intensive prophylaxis may be beneficial.
School of Medicine
General Internal Medicine
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