Tumor detection using computational fiberscope system
Biomed Phys Eng Express
© 2019 IOP Publishing Ltd. Acomputational fiberscope systemhas been designed and developed to detect and quantify an optical source deep in a homogeneousmediumby quickly determining tissue optical properties (absorption coefficient ma and transport scattering coefficient m).Our systemdetermined the optical properties ma and m with average difference of 2.0%and 14.8%between this study and reference. Location of source is 0.15 cmfromreference position. Diffuse light was collected by an optical fiber based fiberscope with a detectingwindowat the end of it. The position and orientation of the detectingwindowof the fiberscope were controlled by a 3Dtracking systemand a rotary stage.Duringmeasurements, the detected signals were recorded using a high-speed data acquisition system. To test the ability of this algorithmto accurately reconstruct the features of an optical source deep in a homogeneous tissuemedium, measurements were performed in a tissue simulating phantom(an aqueous suspension of 5.5 L 3% Liposyn-10%).The currentmethod is effective for samples whose optical properties satisfy the requirement of the diffusion approximation.Our results indicate that the customdesigned fiberscope systemhas a potential for tumor sensing in fluorescent applications on patients.
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