Eruptions and Related Clinical Course Among 296 Hospitalized Adults with Confirmed COVID-19.
J Am Acad Dermatol
Limited information exists on mucocutaneous disease and its relation to course of COVID-19.
To estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19.
Prospective cohort study at two tertiary hospitals (Northwell Health) between May 11, 2020 and June 15, 2020.
Among 296 hospitalized adults with COVID-19, 35 (11.8%) had at least one disease-related eruption. Patterns included ulcer (13/35, 37.1%), purpura (9/35, 25.7%), necrosis (5/35, 14.3%), non-specific erythema (4/35, 11.4%), morbilliform eruption (4/35, 11.4%), pernio-like lesions (4/35, 11.4%), and vesicles (1/35, 2.9%). Patterns also demonstrated anatomic site-specificity. A greater proportion of patients with mucocutaneous findings used mechanical ventilation [61% vs. 30%], used vasopressors [77% vs. 33%], initiated dialysis [31% vs. 9%], had thrombosis [17% vs. 11%], and had in-hospital mortality [34% vs. 12%] compared to those without mucocutaneous findings. Patients with mucocutaneous disease were more likely to use mechanical ventilation [adjusted PR 1.98 (1.37-2.86); PLimitationsSkin biopsies were not performed.
Distinct mucocutaneous patterns were identified in hospitalized adults with COVID-19. Mucocutaneous disease may be linked to more severe clinical course.
Faculty; Northwell Researcher; SOM Student
School of Medicine; Northwell Health
Hospital Medicine; COVID-19 Publications