Title
Vitamin K antagonists' use and fracture risk: results from a systematic review and meta-analysis: reply
Publication Date
2016
Journal Title
J Thromb Haemost
Abstract
We thank Zhou and colleagues [1] for their careful reading of our recently published meta-analysis [2] in which we assessed the potential relationship between vitamin K antagonists and bone mineral density as well as fracture risk, and for their thoughtful comments. The authors raise the following five concerns regarding study methodology and data display: multiple testing; potential for type-I error; handling of heterogeneity of results and use of random effects models throughout; method of quality assessment; and data display in forest and funnel plots. This article is protected by copyright. All rights reserved.
Volume Number
14
Issue Number
1
Pages
221-3
Document Type
Article
EPub Date
2015/11/12
Status
Faculty
Facility
School of Medicine
Primary Department
Psychiatry
Additional Departments
Molecular Medicine
PMID
DOI
10.1111/jth.13180