Title

Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure

Publication Date

2015

Journal Title

J Thromb Haemost

Abstract

Acquired factor V (FV) inhibitors occur rarely and classically develop after exposure to bovine thrombin. The clinical presentation is variable, ranging from asymptomatic with incidental laboratory abnormalities to significant bleeding. With the development of human-derived thrombin agents, bovine thrombin is less frequently used. We report a case of an acquired FV inhibitor that developed in a patient after exposure to human thrombin used as a hemostatic agent during an otorhinolaryngology surgical procedure. Our review of the literature revealed only one prior reported case of FV inhibitor after exposure to human thrombin. Hematologists and surgeons should be aware of this rare, but potentially life-threatening, complication in the postprocedural setting.

Volume Number

13

Issue Number

10

Pages

1787-9

Document Type

Article

EPub Date

2015/08/14

Status

Faculty; Northwell Researcher

Facility

School of Medicine; Northwell Health

Primary Department

Pathology and Laboratory Medicine

Additional Departments

Medicine

PMID

26270511

DOI

10.1111/jth.13114