Title
Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure
Publication Date
2015
Journal Title
J Thromb Haemost
Abstract
Acquired factor V (FV) inhibitors occur rarely and classically develop after exposure to bovine thrombin. The clinical presentation is variable, ranging from asymptomatic with incidental laboratory abnormalities to significant bleeding. With the development of human-derived thrombin agents, bovine thrombin is less frequently used. We report a case of an acquired FV inhibitor that developed in a patient after exposure to human thrombin used as a hemostatic agent during an otorhinolaryngology surgical procedure. Our review of the literature revealed only one prior reported case of FV inhibitor after exposure to human thrombin. Hematologists and surgeons should be aware of this rare, but potentially life-threatening, complication in the postprocedural setting.
Volume Number
13
Issue Number
10
Pages
1787-9
Document Type
Article
EPub Date
2015/08/14
Status
Faculty, Northwell Researcher
Facility
School of Medicine; Northwell Health
Primary Department
Pathology and Laboratory Medicine
Additional Departments
Hematology/Medical Oncology
PMID
DOI
10.1111/jth.13114